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Quilty effect

Quilty effect refers to lymphocytic infiltrates in the endocardium of cardiac allografts. Quilty effect is generally not regarded as a manifestation of rejection and should be distinguished from focal interstitial lymphoid infiltrates of cellular rejection.

It was suggested that Quilty effect may be related to a relatively low concentration of cyclosporine A in the endocardium. In this contest, it can be regarded as localized focal rejection of no clinical significance.

Some data suggest that the presence of Quilty effect, while not being a sign of rejection in itself, correlates with the risk of acute cellular rejection, probably through the same immunological mechanisms.

  1. E. Di Carlo, T. D'Antuono, S. Contento, M. Di Nicola, E. Ballone and C. Sorrentino. Quilty Effect Has the Features of Lymphoid Neogenesis and Shares CXCL13-CXCR5 Pathway With Recurrent Acute Cardiac Rejections. American Journal of Transplantation.Vol. 7, Issue 1, 2006: 201-210
  2. Michael Zakliczynski, Jerzy Nozynski, Dominika Konecka-Mrowka, Lukasz Pyka, Dominika Trybunia, Marcin Swierad, Marcin Maruszewski, Marian Zembala. Quilty Effect Correlates With Biopsy-proven Acute Cellular Rejection But Does Not Predict Transplanted Heart Coronary Artery Vasculopathy. The Journal of Heart and Lung Transplantation. Vol. 28, Issue 3, March 2009: 255-259

Last updated: May 3, 2012, 11:08 am EST

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Quilty effect

Quilty effect
(Click to enlarge)

Quilty effect in the endocardium of a transplanted allograft heart (H&E, 400x). The lymphocytic infiltrate is confined to the endocardium.