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Quilty effect

Quilty effect refers to lymphocytic infiltrates in the endocardium of cardiac allografts. Quilty effect is generally not regarded as a manifestation of rejection and should be distinguished from focal interstitial lymphoid infiltrates of cellular rejection.

It was suggested that Quilty effect may be related to a relatively low concentration of cyclosporine A in the endocardium. In this contest, it can be regarded as localized focal rejection of no clinical significance.

Some data suggest that the presence of Quilty effect, while not being a sign of rejection in itself, correlates with the risk of acute cellular rejection, probably through the same immunological mechanisms.

References:
  1. E. Di Carlo, T. D'Antuono, S. Contento, M. Di Nicola, E. Ballone and C. Sorrentino. Quilty Effect Has the Features of Lymphoid Neogenesis and Shares CXCL13-CXCR5 Pathway With Recurrent Acute Cardiac Rejections. American Journal of Transplantation.Vol. 7, Issue 1, 2006: 201-210
  2. Michael Zakliczynski, Jerzy Nozynski, Dominika Konecka-Mrowka, Lukasz Pyka, Dominika Trybunia, Marcin Swierad, Marcin Maruszewski, Marian Zembala. Quilty Effect Correlates With Biopsy-proven Acute Cellular Rejection But Does Not Predict Transplanted Heart Coronary Artery Vasculopathy. The Journal of Heart and Lung Transplantation. Vol. 28, Issue 3, March 2009: 255-259


Last updated: May 3, 2012, 11:08 am EST

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Quilty effect

Quilty effect
(Click to enlarge)

Quilty effect in the endocardium of a transplanted allograft heart (H&E, 400x). The lymphocytic infiltrate is confined to the endocardium.