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Rosenthal fibers

Rosenthal fibers are brightly eosinophilic corkscrew shaped structures seen on hematoxylin and eosin (H&E) stained sections of brain tissue. They are non-specific but are frequently seen in pilocytic astrocytoma, reactive gliosis and Alexander disease.

Rosenthal fibers are composed of clumped intermediate filaments of glial fibrillary acidic protein (GFAP).

Last updated: May 31, 2012, 1:01 pm EST

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