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Arias-Stella reaction

Arias-Stella reaction (Arias-Stella phenomenon) is a complex of histomorphogic changes in the endometrium indicative of the presence of chorionic tissue. Morphologically, it is characterized by tortuous, back to back, hypersecretory endometrial glands lined by cells with abundant clear or eosinophilic cytoplasm and enlarged hyperchromatic nuclei that show a various degree of atypia.

The above changes can be induced by pregnancy (uterine or ectopic) or hormone producing neoplasms. The clinical and pathologic significance of Arias-Stella reaction seen in an endometrial specimen may be in mimicking neoplasia or being a diagnostic clue to ectopic pregnancy.


Last updated: May 21, 2012, 2:41 pm EST

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